abstract：:Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal traje...

journal_title：Cells

authors： Mondello S,Guedes VA,Lai C,Czeiter E,Amrein K,Kobeissy F,Mechref Y,Jeromin A,Mithani S,Martin C,Wagner CL,Czigler A,Tóth L,Fazekas B,Buki A,Gill J

更新日期：2020-04-15 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative and inflammatory joint disorder with cartilage loss. Dental pulp stem cells (DPSCs) can undergo chondrogenic differentiation and secrete growth factors associated with tissue repair and immunomodulation. Leukocyte- and platelet-rich fibrin (L-PRF) emerges in regenerative medicine ...

journal_title：Cells

authors： Lo Monaco M,Gervois P,Beaumont J,Clegg P,Bronckaers A,Vandeweerd JM,Lambrichts I

更新日期：2020-04-15 00:00:00

abstract：:Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular differentiation processes, screening small-molecule drugs, modeling...

journal_title：Cells

authors： Tasca F,Wang Q,Gonçalves MAFV

更新日期：2020-04-13 00:00:00

abstract：:Liver fibrosis is a common feature of sustained liver injury and represents a major public health problem worldwide. Fibrosis is an active research field and discoveries in the last years have contributed to the development of new antifibrotic drugs, although none of them have been approved yet. Liver sinusoidal endot...

journal_title：Cells

authors： Lafoz E,Ruart M,Anton A,Oncins A,Hernández-Gea V

更新日期：2020-04-10 00:00:00

abstract：:Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in rheumatoid arthritis (RA). However, the functions of IL-26 produced by macrophages in RA have not been elucidated. In the present work, we evaluated the effects and the mechanisms of IL-26 on M1 and M2 macrophage differentiation. Hu...

journal_title：Cells

authors： Lin YH,Wang YH,Peng YJ,Liu FC,Lin GJ,Huang SH,Sytwu HK,Cheng CP

更新日期：2020-04-10 00:00:00

abstract：:Rice (Oryza sativa L.) seedlings grown under nitrogen (N) deficiency conditions show a foraging response characterized by increased root length. However, the mechanism underlying this developmental plasticity is still poorly understood. In this study, the mechanism by which N deficiency influences rice seminal root gr...

journal_title：Cells

authors： Wang Q,Zhu Y,Zou X,Li F,Zhang J,Kang Z,Li X,Yin C,Lin Y

更新日期：2020-04-09 00:00:00

abstract：:Wnt/β-catenin signaling plays vital role in the regulation of cellular proliferation, migration, stem cells cell renewal and genetic stability. This pathway is crucial during the early developmental process; however, the distinct role of Wnt/β-catenin signaling during pre-implantation period of bovine embryonic develo...

journal_title：Cells

authors： Sidrat T,Khan AA,Idrees M,Joo MD,Xu L,Lee KL,Kong IK

更新日期：2020-04-09 00:00:00

abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...

journal_title：Cells

authors： Sieńko K,Poormassalehgoo A,Yamada K,Goto-Yamada S

更新日期：2020-04-04 00:00:00

abstract：:Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, is present abundantly in citrus peels and has been reported to possess anti-cancer ...

journal_title：Cells

authors： Yen JH,Lin CY,Chuang CH,Chin HK,Wu MJ,Chen PY

更新日期：2020-04-03 00:00:00

abstract：:Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...

journal_title：Cells

authors： Dimitrova-Shumkovska J,Krstanoski L,Veenman L

更新日期：2020-04-02 00:00:00

abstract：:The blood-brain barrier (BBB) is one of the most complex and selective barriers in the human organism. Its role is to protect the brain and preserve the homeostasis of the central nervous system (CNS). The central elements of this physical and physiological barrier are the endothelial cells that form a monolayer of ti...

journal_title：Cells

authors： Saint-Pol J,Gosselet F,Duban-Deweer S,Pottiez G,Karamanos Y

更新日期：2020-04-01 00:00:00

abstract：:The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic effects, such as, for instance, immunosuppression or allergenic promotion. Alternariol (AOH) is one of the most abundant mycotoxins produced by...

journal_title：Cells

authors： Del Favero G,Mayer RM,Dellafiora L,Janker L,Niederstaetter L,Dall'Asta C,Gerner C,Marko D

更新日期：2020-03-31 00:00:00

abstract：:Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...

journal_title：Cells

authors： Romeo-Guitart D,Casas C

更新日期：2020-03-27 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle...

journal_title：Cells

authors： Owens DJ,Fischer M,Jabre S,Moog S,Mamchaoui K,Butler-Browne G,Coirault C

更新日期：2020-03-27 00:00:00

abstract：:Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies to take advantage of and/or modulate cellular autophagy. Several ...

journal_title：Cells

authors： Sher AA,Gao A,Coombs KM

更新日期：2020-03-26 00:00:00

abstract：:Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to fo...

journal_title：Cells

authors： Tebbe L,Kakakhel M,Makia MS,Al-Ubaidi MR,Naash MI

更新日期：2020-03-24 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many ce...

journal_title：Cells

authors： Pant K,Peixoto E,Richard S,Gradilone SA

更新日期：2020-03-23 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...

journal_title：Cells

authors： Ibtisham F,Honaramooz A

更新日期：2020-03-18 00:00:00

abstract：:S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated. The aim of this study is to investigate the possible role of a small molecule abl...

journal_title：Cells

authors： Di Sante G,Amadio S,Sampaolese B,Clementi ME,Valentini M,Volonté C,Casalbore P,Ria F,Michetti F

更新日期：2020-03-18 00:00:00

abstract：:Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...

journal_title：Cells

authors： Hong CT,Chen KY,Wang W,Chiu JY,Wu D,Chao TY,Hu CJ,Chau KD,Bamodu OA

更新日期：2020-03-17 00:00:00

abstract：:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...

journal_title：Cells

authors： Duda P,Hajka D,Wójcicka O,Rakus D,Gizak A

更新日期：2020-03-16 00:00:00

abstract：:The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and ...

journal_title：Cells

authors： Paluszczak J

更新日期：2020-03-15 00:00:00

abstract：:Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the ...

journal_title：Cells

authors： Kristiani L,Kim M,Kim Y

更新日期：2020-03-14 00:00:00

abstract：:: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcr...

journal_title：Cells

authors： Lapitz A,Arbelaiz A,O'Rourke CJ,Lavin JL,Casta A,Ibarra C,Jimeno JP,Santos-Laso A,Izquierdo-Sanchez L,Krawczyk M,Perugorria MJ,Jimenez-Aguero R,Sanchez-Campos A,Riaño I,Gónzalez E,Lammert F,Marzioni M,Macias RIR,Marin

更新日期：2020-03-14 00:00:00

abstract：:The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening. Nowadays, three-dimensional (3D) cultures, including spheroids, are acknowledged to be a better model of the in viv...

journal_title：Cells

authors： Demuynck R,Efimova I,Lin A,Declercq H,Krysko DV

更新日期：2020-03-13 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...

journal_title：Cells

authors： Chu YH,Su CW,Hsieh YS,Chen PN,Lin CW,Yang SF

更新日期：2020-03-13 00:00:00

abstract：:(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...

journal_title：Cells

authors： Schwarz-Cruz Y Celis A,Ceballos-Cancino G,Vazquez-Santillan K,Espinosa M,Zampedri C,Bahena I,Ruiz V,Maldonado V,Melendez-Zajgla J

更新日期：2020-03-13 00:00:00

abstract：BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...

journal_title：Cells

authors： Serrano R,Wesch D,Kabelitz D

更新日期：2020-03-13 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML). The nucleus is a highly organized organelle with several distinct domains where...

journal_title：Cells

authors： Xian J,Owusu Obeng E,Ratti S,Rusciano I,Marvi MV,Fazio A,De Stefano A,Mongiorgi S,Cappellini A,Ramazzotti G,Manzoli L,Cocco L,Follo MY

更新日期：2020-03-12 00:00:00

abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...

journal_title：Cells

authors： Bot I,Velden DV,Bouwman M,Kröner MJ,Kuiper J,Quax PHA,de Vries MR

更新日期：2020-03-12 00:00:00

abstract：:We prepared cellulose nanofibrils-based (CNF), alginate-based and single-walled carbon nanotubes (SWCNT)-based inks for freeform reversible embedding hydrogel (FRESH) 3D bioprinting of conductive scaffolds. The 3D printability of conductive inks was evaluated in terms of their rheological properties. The differentiati...

journal_title：Cells

authors： Bordoni M,Karabulut E,Kuzmenko V,Fantini V,Pansarasa O,Cereda C,Gatenholm P

更新日期：2020-03-11 00:00:00

abstract：:Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1). The mechanisms of the stimulus-secretion coupling involve the participation of the key enzymes that metabolize the nutrients, and numerous ion ...

journal_title：Cells

authors： Islam MS

更新日期：2020-03-11 00:00:00

abstract：:Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and wid...

journal_title：Cells

authors： Zaiou M

更新日期：2020-03-09 00:00:00

abstract：:Circulating tumor cells (CTCs) as real-time liquid biopsy [...]. ...

journal_title：Cells

authors： Alix-Panabières C

更新日期：2020-03-09 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) from various sources exhibit different potential for stemness and therapeutic abilities. Recently, we reported a unique MSCs from human palatine tonsil (TMSCs) and their superior proliferation capacity compared to MSCs from other sources. However, unique characteristics of each MSC are...

journal_title：Cells

authors： Seo Y,Shin TH,Ahn JS,Oh SJ,Shin YY,Yang JW,Park HY,Shin SC,Kwon HK,Kim JM,Sung ES,Park GC,Lee BJ,Kim HS

更新日期：2020-03-06 00:00:00

abstract：:Synchronous communication between the developing embryo and the receptive endometrium is crucial for embryo implantation. Thus, uterine receptivity evaluation is vital in managing recurrent implantation failure (RIF). The potential roles of small extracellular vesicle (sEV) miRNAs in pregnancy have been widely studied...

journal_title：Cells

authors： Tan Q,Shi S,Liang J,Zhang X,Cao D,Wang Z

更新日期：2020-03-06 00:00:00

abstract：:As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain overcome antibody size and complexity while maintaining analogous binding loops. However, antibodies and their derivatives remain the gold standard for the design of new therapeutics. In response, clinical-stage therapeutic proteins ...

journal_title：Cells

authors： Chandler PG,Buckle AM

更新日期：2020-03-04 00:00:00

abstract：:Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell typ...

journal_title：Cells

authors： Santos J,Hubert T,Milthorpe BK

更新日期：2020-03-04 00:00:00

abstract：:Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties....

journal_title：Cells

authors： Moretti E,Favero G,Rodella LF,Rezzani R

更新日期：2020-03-03 00:00:00

abstract：:The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in workload by hypertrophic growth primarily by individual cardiac myocyte...

journal_title：Cells

authors： Blackwood EA,Bilal AS,Stauffer WT,Arrieta A,Glembotski CC

更新日期：2020-03-03 00:00:00